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Opioid withdrawal symptoms might include: Extreme cravings for more of your drug of choice Sweats Chills Fever Runny nose Tremors Head-to-toe body aches Stomach pain Nausea Diarrhea Migraine headaches Loss of appetite Insomnia Sleep disturbance Nightmares Lack of motivation Loss of mental focus Brain fog Extreme anxiety Overwhelming depression The need to isolate and withdraw from social relationships Extreme fatigue and physical exhaustion Seizures, coma, or death (in extreme cases) Again, the severity of these symptoms and how long they last varies from person to person