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Saponins: These bitter compounds have certain anti-inflammatory and cholesterol-lowering properties
Clinicians who specialize in obesity medicine, such as Jesse Richards at the University of Oklahoma in Tulsa, argue that the benefits may outweigh the risks for some patients
For example, in the liver affected by NAPQI, severity of injury may range from full necrosis in hepatocytes immediately around the central vein, to cells in the midzonal region that still survive, but have undergone adaptive responses as they continue to experience persistent JNK activation and oxidant stress, but have not yet reached an irreversible sustained MPT, to periportal hepatocytes that are minimally affected or undergoing successful repair
It can currently only be accessed in the UK through approved clinical trials operating under regulatory and ethical oversight
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