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Collectively, these data reveal that exendin 2029 acts as a key sequence in inducing analgesia in CAP-elicited nociceptive behaviors in mice without causing hyperthermia, and this analgesic effect is mediated by exendin 2029 directly inhibiting CAP-induced TRPV1 activation but not proton-induced TRPV1 activation
Modest weight loss often produces substantial symptom improvement independent of other interventions
These actions improve glucose control in type 2 diabetes patients who have weak GLP-1 response
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