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The SURMOUNT-OSA trial demonstrated: Mean AHI reduction of approximately 25 to 30 events per hour at 15 mg tirzepatide Significant percentage of patients moving from severe to mild OSA classification Effects observed in both CPAP-using and non-CPAP-using populations Concurrent weight loss consistent with SURMOUNT-1 outcomes Coverage under the OSA pathway has expanded steadily through 2025 and into 2026 across OptumRx-administered plans

By combining the effects of semaglutide and B12, this therapy provides a holistic approach to managing blood glucose, supporting weight loss, and preventing vitamin B12 deficiency

PMID 10708558

For a closer look at how semaglutide costs break down across different payment scenarios, read our complete cost guides here: Ozempic cost without insurance: What to expect in 2026 What does Wegovy cost without insurance