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This pattern is reported across forums and is consistent with IGF-1's known effects on intracellular hydration and protein synthesis through PI3K/Akt/mTOR (Yoshida & Delafontaine, 2020)

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Therefore, homocysteine may not actually be a risk factor but a risk marker for heart disease, harmful when elevated due to other factors that increase heart disease risk, such as a diet rich in red meat and low in fruits and vegetables or smoking [67]