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The methylation of DNA is particularly important, as it helps to regulate gene expression and maintain the integrity of the genome

Since either metformin or GLP-1 analogue has vascular protective effects 7,24 , we reasonably hypothesized that this combination therapy might also have a synergistic protective effect on endothelial function

Finally, Achari reiterated the need for more research in healthy populations rather than extrapolating from existing studies

Alterations on the delivery of nutrients to the small intestine resulting from the fundoplication, which decreases the accommodating capacity of the stomach, may explain the rapid rise in glucose and enhanced GLP-1 release