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This interaction may induce alterations in the receptor's conformation, possibly sparking a chain of molecular events that might activate signaling pathways within its target cells

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Significantly, melatonin supplementation has demonstrated the capacity to alleviate oxidative stress and impede the accumulation of A, as well as tau hyperphosphorylation, in the hippocampus of aged rats exhibiting brain insulin resistance induced by a high-fat diet [135]

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