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Third, it upregulates VEGFR2 and activates the VEGFR2-Akt-eNOS pathway, accelerating blood vessel formation and blood flow recovery in ischaemic tissue, a mechanism confirmed in endothelial cell culture and rat hind-limb ischaemia models by Hsieh 2017

Lednicky JA, Tagliamonte MS, White SK, Elbadry MA, Alam MM, Stephenson CJ, et al

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Animals also presented a reduction of tight junction protein ZO-1, suggesting other effects into BBB, and exhibited augment in lipid peroxidation in the brain [29]