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Description

The release of GLP-1 follows a biphasic pathway: an initial peak mediated by neural signalling, followed by a second phase which is triggered by direct mechanical stimulation of L-cells, as nutrients pass through the gut (18)

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A recent meta-analysis of data from seven double-blind randomized controlled trials with tirzepatide lasting at least 26 weeks confirmed the cardiovascular safety of tirzepatide in patients with T2D (77)

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They do not activate the GLP-1 receptor with the same potency, which means your expected dose effectively becomes a smaller dose

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Zhang Q

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