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The dominant clinical question is whether these benefits are downstream consequences of weight loss, glycemic improvement, and blood-pressure reduction, or whether they reflect direct pleiotropic actions on the vascular wall and myocardium

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CD, n=258) who were prescribed a GLP1RA (liraglutide, semaglutide, tirzepatide) at least twice, identified on the Mayo Clinic Platform, included in this study, and matched with controls with IBD but not treated with GLP1RA

The bone and cartilage repair community learned this lesson early: incomplete protocols often produce no measurable benefit, and the same principle applies with even greater force to neurological applications where the biological timelines are longer