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Although the underlying contributors to these differences cannot be determined from observational data, potential factors may include variation in baseline clinical characteristics, access to care, treatment persistence, dose escalation, social determinants of health, and unmeasured biological heterogeneity

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It has more to do with brain signals associated with GLP-1 use than any active dysfunction

For urgent situations, such as suicidal thoughts or behaviors, you should call 911 and go to the emergency room or call or text 988 for the Suicide & Crisis Lifeline