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When you swallow a B12 pill, several steps have to work for it to be absorbed: stomach acid and the enzyme pepsin must release B12 from food or the supplement, the stomach must secrete a protein called intrinsic factor that binds to B12, and the B12-intrinsic factor complex must reach the ileum (the end of the small intestine) where it is finally absorbed

In other words, it should only be used as a vehicle for other drugs, not as fluid replacement

Once the substance enters the capillaries surrounding the stomach and small intestines, it enters passageways that lead to the portal vein, which passes through the liver and branches out into the capillaries

Their brains show reduced activity in prefrontal regions responsible for executive control, making it difficult to resist immediate gratification in favor of long-term goals