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"Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157 in rats and dogs." Frontiers in Pharmacology , 2022

We did not observe any change in spontaneous physical activity level and we found that calorie-matched group did not lose weight to the same extent as the Melanotan-treated animals, suggesting that the drug increases energy expenditure

Wegovy, which uses the same active molecule at a 2.4 mg dose and is FDA-approved specifically for chronic weight management, was excluded

Most patients receive initial instruction from a practice nurse or healthcare professional before attempting home administration