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It has high potency for GH release in vitro and in vivo, with minimal stimulation of cortisol or ACTH, thereby helping to avoid many side effects commonly associated with less specific GH secretagogues

It is primarily secreted by the L-cells of the intestines in response to food intake, acting as an incretin hormone that stimulates insulin secretion in a glucose-dependent manner while inhibiting glucagon release from the pancreas

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But to change muscle fuel preference and endurance capacity, human studies that saw measurable increases in muscle carnitine used daily dosing for many weeks combined with carbohydrate to produce insulinmediated uptake