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Systemic metabolic alterations and their relationship to neuropsychiatric symptomatology PAIS, including long COVID, as well as CFS and IMD, share the characteristic of systemic metabolic disturbances, which may be a sign of underlying multi-organ inflammation and exhaustion [31], and consequently may contribute to neuropsychiatric symptomatology, as many metabolites can cross the bloodbrain barrier (BBB) [30, 58] (e.g., short chain fatty acids (SCFAs) derived from the gut microbiota such as acetate [40], amino acids such as tryptophan [52] and also carnitine/acetylcarnitine can cross the BBB via transporters [59])
Sugary Drinks and Fruit Juices Sugary drinks like soda or processed fruit juices might taste good in the moment, but they can spike your blood sugar quicklywhich is the opposite of what we want when youre taking metformin
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The mechanism may be related to inhibiting ATG16L1-mediated autophagy of normal colon epithelial cells, promoting ROS accumulation and NLRP3 inflammasome assembly
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