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For 10 days, healthy subjects received 10 mg of oral semaglutide (formulation R1) once daily doses with 50 mL or 120 mL of water under fasting conditions with post-dose fasting period of 15, 30, 60 or 120 minutes

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Its extended half-life makes it a powerful research tool but also means its effects persist much longer than natural IGF-1

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Generic availability also reduces payer resistance, since the per-member cost has dropped below many specialty drug thresholds

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Wharton S, Calanna S, Davies M, Dicker D, Goldman B, Lingvay I, Mosenzon O, Rubino DM, Thomsen M, Wadden TA, Pedersen SD

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