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GLP-1 medicines in neuro- and cardiovascular inflammation Microglia secrete pro-inflammatory cytokines upon activation, stimulating nearby reactive astrocytes and amplifying local neuroinflammation

Over the following weeks most people notice steadier energy and fewer afternoon crashes first (weeks 12), then early fat loss around the midsection with workouts feeling more productive (weeks 24), then measurable body-fat reduction and better endurance and recovery (weeks 48), with metabolic markers like glucose and triglycerides often improving by week 8+

proposed that TB-500 may support cellular resilience in aging tissue laboratory models by reminding adult organ systems of earlier developmental signaling states, suggesting broader relevance to stress-related cellular programs beyond cytoskeletal function alone

doi: 10.1186/s12935-025-03944-2