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Studies have shown that compared with more traditional histopathological classifications, cancer classifications based on molecular data may prove to be more clinically impactful in terms of predicting treatment and patient prognosis 4,5
In this 52-week trial of 1,698 people with type 2 diabetes whose blood sugar wasn't adequately controlled on Metformin, orforglipron outperformed oral semaglutide on every primary and secondary endpoint, including A1C reduction and weight loss, with improvements visible as early as four weeks
Given the metabolic benefits of GLP-1RAs, caution is advised in patients with a history of depression or psychiatric vulnerability and a heightened vigilance for these events is warranted
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