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Across preclinical research and clinical studies, cagrilintide has been evaluated for effects on body weight, energy intake, and metabolic parameters, including work that explores combination approaches (such as pairing with semaglutide)

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Many users report a softer, smoother feel within the first 24 weeks of consistent use, with broader changes in skin tone, fine lines, and elasticity typically reported over 8 to 12 weeks

Notably, completed and ongoing studies such as NCT06475586, NCT06937060, NCT06588296, and NCT06864026 are investigating semaglutide in patients with PsO and comorbid metabolic conditions, or tirzepatide (in PsA settings), assessing dermatologic outcomes and inflammatory or metabolic markers (78, 79)