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Macrophages exhibit a heterogeneous and plastic phenotype, capable of polarizing into the pro-inflammatory M1 or the reparative and anti-inflammatory M2 phenotypes

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Indeed, polymorphism in the Arsenic (+3 oxidation state) MethylTransferase ( AS3MT ) gene has been demonstrated to be a strong determinant of arsenic methylation capacity and related health outcomes as covered in reviews by Abuawad et al (2021) and Thomas (2021)