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MDD is the most common form, affecting 15-20% of the population in the USA

Critical structural modifications, such as C-terminal amidation and the presence of histidine at position 7, enhance their therapeutic efficacy and extend their half-life

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This dual approach, direct ROS scavenging through electron donation and indirect antioxidant enhancement via Nrf2 activation, explains ESCs effectiveness in various cases of oxidative stress-related diseases (Jayakumar et al