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Interestingly, their analysis demonstrated that different GS-like enzymes accepted various alternate nucleophiles, including d-serine, non-natural amino acids, and alpha-amino alcohols, to yield a range of glutathione variants, but did not produce either serine- or glutamate-substituted analogs
10.1002/advs.202001549 12 DongY.DongS.LiuB.YuC.LiuJ.YangD.et al (2021)
Mutations and damage to mitochondrial DNA can affect the function of oxidative phosphorylation complexes, leading to increased ROS generation
It then converts into the neurotransmitter dopamine
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