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PMID 16399504
Given the difficulty of targeting endothelial cells in the dermis, inhibiting downstream pathways activating melanocytes, like EDN-1/EDN receptor signaling [176,177,178,179], could be particularly relevant for treating melasma and solar lentigo as this signaling pathway is upregulated in these conditions [180]
The body composition test known as a DEXA scan is used to measure body fat more accurately than BMI
You can also take supplements to get the vitamin B12 that your body needs
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