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Nauck MA, Petrie JR, Sesti G, et al
Pinch a fold of skin approximately 1 inch thick at the injection site (abdomen preferred, at least 2 inches from navel) [10]
Long-term use at the recommended dose is fine, but high doses over prolonged periods may cause issues like hypopigmented patches, lightened hair color, and increased melanoma risk
Small uncontrolled step-down and reduced-frequency series also suggest that some users can hold a plateau with less exposure, but no randomized trial has tested reducing stable 2.4 mg users into this band
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