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Evolution and mechanism of action of beta-blockers Types of betablockers: Nonselective betablockers Selective betablockers Betareceptor Location: Heart Positive chronotropic effects (increases heart rate) Positive inotropic effects (increases contractility of the myocardium) Kidney Increased release of renin, which in turn increases blood pressure Betareceptor Location: Smooth muscle cells Promotes relaxation Skeletal muscle cells Promotes tremor and increased glycogenolysis Liver Increases glycogenolysis Betareceptor Location: Adipose tissue Induces lipolysis Administration: intravenous and oral Firstgeneration nonselective betablockers Affect all betareceptors

This selectivity makes it a preferred tool in GH research where hormonal specificity matters

Its about how fat pushes against the connective tissue under your skin