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doi: 10.3390/cells10071647 27 ZhangHWangSQHangLZhangCFWangLDuanCJet al

Individuals who were more explicitly biased against overweight individuals, individuals with a low level of empathy for overweight individuals, and who believed that people are completely responsible for their own weight showed some tendency in one study to judge GLP-1RA users more harshly, although these effects were modest and not consistently observed across both studies

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It arises due to a combination of genetic and lifestyle factors that contribute to defective production of insulin from pancreatic beta cells, and/or resistance to its uptake by insulin receptors located in peripheral and central tissues in the body