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Both components of CS10 are acylated peptides with a long half-life thanks to albumin binding which explains the convenient, weekly dosing schedule used in clinical protocols for the combination
the mitochondrial multienzyme complexes of 2-oxo acids, i.e., of pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH), 2-oxoadipate dehydrogenase (OADH) and branched chain 2-oxo acid dehydrogenase (BCODH), linked to amino acids through their transamination to the 2-oxo acids
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However, in the presence of hypoxia and excess hemin exposure along with supraphysiological concentrations of cystine, we readily detected the ability of DMF in contributing cysteine availability (Fig
