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Melatonin is a hormone naturally produced in the pineal gland that primarily regulates the bodys sleep-wake cycle or circadian rhythm

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While this extended half-life reduces dosing frequency, it also creates more constant GH rise that may not keep natural pulsatile patterns as effectively

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doi: 10.1128/mBio.02221-18 135 Rosario-ColonJ.EberleK.AdamsA.CourvilleE.XinH

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