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Quick Answer: GLP-1 receptor agonists do not directly increase fracture risk, but substantial weight loss during treatment may indirectly reduce bone mineral density at weight-bearing sites
Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $32.99 / 30 days cancel any time Subscribe to this journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout Nature Medicine 32 , 2-3 (2026) doi:
By working with your bodys natural hormone signaling, semaglutide helps reduce hunger, improve fullness, and make consistent weight loss feel more achievableespecially for individuals who have struggled with traditional methods
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