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Adjunctive topical agents may be applied during treatment depending on clinical judgement
As shown in Section Riboflavin Ameliorates Oxidative Stress, Mitochondrial Dysfunction, and Neuroinflammation, riboflavin has antioxidant properties and upregulates antioxidant enzymes especially SOD, also, supplementation with riboflavin will elevate the intra-mitochondrial FAD levels compensating for the decline in the capacity to assemble of dysfunctional mitochondrial complexes
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