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As erythrocytes lack intracellular organelles, their metabolism is restricted to well-known cytosolic biochemistry: glycolysis, the pentose phosphate pathway (PPP), redox metabolism, oxygen metabolism, purine/nucleoside metabolism, and membrane transport

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Noureddin M, Rinella M, Taub R, et al

Comparing the Approaches When deciding whether to use one or both, it is helpful to see how they stack up in terms of administration and primary focus