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In the LEADER trial, over 9,340 patients with type 2 diabetes and high cardiovascular disease risk underwent randomization to liraglutide or placebo and were followed for a median of 3.8 years resulting in a 13% risk reduction in a combined endpoint of death from cardiovascular cause, nonfatal myocardial infarction, or nonfatal stroke [46]

Furthermore, the gut-brain-pancreas axis is connected via the parasympathetic vagus nerve with afferent neurons linking the intestinal mucosa, portal vein and hypothalamus

They include: Nausea Vomiting Diarrhea Decreased appetite Constipation Abdominal pain These gastrointestinal issues are the most frequently reported side effects, occurring in up to 20% of patients in clinical trials

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