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Based on previous experimental evidence, we hypothesize that the reduction in circulating BDNF levels early after bariatric surgery may serve as a counter-regulatory response to sustained caloric restriction, weight loss and improved insulin sensitivity, whereas increased BDNF later after bariatric surgery may help improve obesity-related neurocognitive disorders and regulate food intake

Sp1-mediated upregulation of Prdx6 expression prevents podocyte injury in diabetic nephropathy via mitigation of oxidative stress and ferroptosis

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*Based on preclinical studies