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The study reveals that BPC-157-induced GHR expression increases sensitivity to growth hormone signaling: adding growth hormone to BPC-157-treated fibroblasts dose- and time-dependently increased cell proliferation (MTT assay and PCNA) and activated the downstream Janus kinase 2 (JAK2) pathway
This hypothesized VEGF/VEGFR interaction may activate a complex intracellular signaling cascade, which may involve multiple proteins such as phospholipase C, protein kinase C, and the mitogen-activated protein kinases
In the literature, BPC-157 doses are reported in micrograms per kilogram of body weight
Because these are intramuscular injections, some patients may experience mild and temporary side effects at the injection site, including: Soreness or tenderness Mild redness or swelling Minor bruising These symptoms are typically minimal and resolve quickly
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