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The binding free energy value serves as an indicator of the binding strength between the ligand and protein, wherein a lower value corresponds to a more favorable docking orientation and a stronger binding interaction
Advances in therapy , 21 , 173-177
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Considering a three-dimensional structural model for a complex of the human HGF-NK2 segment sandwiched by c-met receptor molecules (see supplementary Figure 3, re-produced from PDB ID 7MO7 67 , it is hypothesized that the disulfide bonds, notably Cys149-Cys189 and Cys177-Cys201 localized internally just behind Y198, are the targets of LASSS
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