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Of approximately 4,000 affected genes, 59% are upregulated while 41% are downregulated, generally shifting expression patterns from diseased toward healthier states
Oral is often preferred for convenience and gut-specific studies, while injectable offers higher bioavailability for systemic or targeted musculoskeletal research
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Participants first lost weight during a 36-week lead-in period on tirzepatide, then were randomized to either continue the medication or switch to placebo for an additional 52 weeks
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