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Insulin, metformin (in select cases), or other established diabetes medications are standard first-line choices during pregnancy because they have decades of human safety data
The double protease approach substantially increased protein sequence coverage
It was investigated as a candidate obesity therapeutic but did not meet its primary endpoints in clinical trials, and no marketing approval followed
doi: 10.1016/S0090-4295(96)00313-5 60 SalehRAAgarwalASharmaRKNelsonDRThomasAJJr
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