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Although long-acting glucagon-like peptide-1 (GLP-1) analogues are now in routine use for diabetes and are now being utilised for obesity per se , the need for ever better treatments has driven the development of co-agonists, with the theoretical advantages of improved efficacy by targeting multiple pathways and reduced adverse effects

These reports raised concerns, but so far larger studies and FDA evaluations have not confirmed a clear increase in risk

MOTS-C's regulatory position has been complicated by its relatively recent emergence in clinical literature

This peptide is usually administered orally through capsules