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Aged mice also exhibited elevated levels of the detrimental molecules spewed by senescent cells, called the SASP (senescence-associated secretory phenotype)
For reference, the FDA label dose of tesamorelin alone is 2 mg/day (legacy formulation) or 1.28 mg/day for the newer EGRIFTA WR formulation, and ipamorelin has been studied at roughly 100-300 mcg per dose in research settings
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Preclinical research Receptor activity, endocrine selectivity, and model-specific biological responses were characterized in early studies
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