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Patients taking GLP-1R agonists lost weight and had a lower risk of knee surgery than patients not taking GLP-1R agonists
However, researchers with active malignancies should avoid use until more data exists
LEADER [29] and SUSTAIN-6 [30] reported a prespecified renal composite of new onset or persistent macroalbuminuria, persistent doubling of serum creatinine and eGFR 45 mL/min/1.73 m 2 , need for renal replacement therapy (RRT), and renal death
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