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It does not prevent oxidation of methionine or tryptophan residues, does not prevent deamidation, and does not prevent aggregation from temperature fluctuation
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thus, the exceeding drugs molecules remain unbound in plasma and can additionally partition into RBCs, apparently increasing their affinity for the erythrocyte compartment ( in vitro and in vivo biocompatibility of membrane-bound molecules, and by appropriate approaches, they have identified the best conditions that do not affect cell clearance ( in vivo longevity of the RBC, so they are considered such an optimal drug delivery system able to avoid the liver and spleen metabolisms (2012