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doi: 10.1098/rsob.200200 190 KimD-GJungKHLeeD-GYoonJ-HChoiKSKwonSWet al

And all melasma is exceedingly tough to tackle, unlike dark spots, which can typically be treated with topicals like retinoids and vitamin C

Expert Opinion on Biological Therapy (2012) 11

Quantification of a Panel of Inflammatory Cytokines The levels of the anti-inflammatory cytokine IL-10 and the pro-inflammatory cytokines TNF-, IL-6, and IL-1 in brain cell homogenates were quantified using specific ELISA kits (Ray Biotech, Peachtree Corners, GA, USA) according to the manufacturers instructions