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After in vitro stimulation with CpG, B cells from older individuals produce significantly lower levels of IgM and IgA antibodies compared to younger individuals, highlighting a diminished capacity to respond to novel pathogens while maintaining responsiveness to frequently encountered antigens [357]

PLoS One 11 , e0159384 (2016)

Efficacy of apixaban when compared with warfarin in relation to renal function in patients with atrial fibrillation: insights from the ARISTOTLE trial