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Raisi-Estabragh Z, Kobo O, Mieres JH, Bullock-Palmer RP, Van Spall HGC, Breathett K, et al
Long-acting agonists include liraglutide, exenatide(Bydureon), albiglutide, dulaglutide, semaglutide, PEG-loxenatide and tirzepatide, which can maintain an appropriate agonist level in plasma throughout the 24 hours of the day
In a phase II trial, adults with a BMI of 30 or 27 kg/m with comorbidities were randomized to receive efpeglenatide at doses of 4 mg weekly, 6 mg weekly, 6 mg biweekly, or 8 mg biweekly, or a placebo, all combined with a hypocaloric diet [17]
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