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Rapamycin pharmacokinetics in humans have previously been shown to be impacted by the consumption of food, with a high-fat meal resulting in reductions in C max but increases in AUC by 23 to 35%.[49] This, however, has not been investigated in dogs.[49] Given this, future investigation into whether food consumption does affect rapamycin absorption in dogs would be valuable, as this might influence the protocol of the upcoming long-term low-dose study, and other uses of rapamycin in this species, by recommending treatment administration at a specified time relative to a meal

Symptoms of deficiency include fatigue, susceptibility to infections, and increased oxidative stress