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Due to the different levels of enzyme defect with various mutations and the different genes there is wide variability in the severity of the clinical symptoms
(Neuropsychobiology 1992) documented a 59% improvement in sleep duration (+130 minutes) in chronic insomniac patients
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Oral bioavailability is expected to be negligible given the peptide's large size, and subcutaneous or intravenous delivery would likely be required for any human application
Glutathione-1- 13 C or N -acetyl-cysteine-1- 13 C (NAC) was orally administered to rats (50 mg/kg)
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