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This trial enrolled 338 adults with obesity and tracked them for 48 weeks across multiple dose groups
Semaglutide is a drug that has been used for diabetes type II and has been recently approved by the NHS for weight loss alongside lifestyle intervention (nutrition and physical activity)
However, rapid weight loss itselfespecially loss exceeding 1-2 pounds weeklycan temporarily shift thyroid hormone metabolism and TSH levels, a phenomenon called weight-loss-related thyroid adaptation
Dose titration, genetic testing, or formulation changes often restore the earlier benefits you experienced
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