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MOTS-c Reconstitution Math MOTS-c - common doses at common vial sizes Vial Size 5 mg BAC Water 1.0 mL Concentration 5 mg/mL 5 mg Dose 1.0 mL (100 units) 2.5 mg Dose 0.50 mL (50 units) 1 mg Dose 0.20 mL (20 units) 200 mcg Dose 0.04 mL (4 units) Vial Size 5 mg BAC Water 2.0 mL Concentration 2.5 mg/mL 5 mg Dose 2.0 mL (200 units*) 2.5 mg Dose 1.0 mL (100 units) 1 mg Dose 0.40 mL (40 units) 200 mcg Dose 0.08 mL (8 units) Vial Size 10 mg BAC Water 1.0 mL Concentration 10 mg/mL 5 mg Dose 0.50 mL (50 units) 2.5 mg Dose 0.25 mL (25 units) 1 mg Dose 0.10 mL (10 units) 200 mcg Dose 0.02 mL (2 units) Vial Size 10 mg BAC Water 2.0 mL Concentration 5 mg/mL 5 mg Dose 1.0 mL (100 units) 2.5 mg Dose 0.50 mL (50 units) 1 mg Dose 0.20 mL (20 units) 200 mcg Dose 0.04 mL (4 units) Vial Size 10 mg BAC Water 3.0 mL Concentration 3.33 mg/mL 5 mg Dose 1.50 mL (150 units*) 2.5 mg Dose 0.75 mL (75 units) 1 mg Dose 0.30 mL (30 units) 200 mcg Dose 0.06 mL (6 units) * Volumes above 100 units exceed a standard 1 mL insulin syringe

The Foundation: Understanding the Players To understand the protocol, it helps to examine the three compounds involved and how they influence cellular metabolism

They also drive vascular remodeling in major arteries, helping to maintain blood pressure, and regulate cell morphology, polarity and migration [204, 205]