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Although the majority of exposures produced mild and self-limited gastrointestinal symptoms, the period was also marked by a significant rise in healthcare facility referrals, increasing from 23.0% before approval to 33.5% after approval

In another investigation by Fahmy et al., B12 serum levels were positively correlated with language, visuospatial, and global cognitive scores but negatively correlated with attention ability in patients with MS [125]

All supported a non-significant difference in rates of hospitalization for HF relative to the placebo (Table 1)