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By activating the JNK signaling pathway, IL-1 significantly upregulates the pro-apoptotic protein Bax, subsequently inducing apoptosis in cerebrovascular endothelial cells and ultimately compromising BBB function through dual mechanisms: disrupting structural integrity and promoting cell death (102)
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Mizunoe Y, Sudo Y, Okita N, Hiraoka H, Mikami K, Narahara T, et al
On the other hand, necrotrophic fungi obtain nutrients by killing infected tissues of the plant host
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